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Abstract #4727

Arterial transit time measured by multi-delay ASL perfusion for evaluating major cerebral artery stenosis/occlusive disease: correlation with 15O-H2O  and 15O2 gas PET-CBF and OEF

Kayo Takeuchi1, Makoto Isozaki2, Masayuki Kanamoto1, Yoshifumi Higashino2, Hidehiko Okazawa3, Kenichiro Kikuta2, R Marc Lebel4, and Hirohiko Kimura1

1Department of Radiology, University of Fukui, Fukui, Japan, 2Department of Neurosurgery, University of Fukui, Fukui, Japan, 3Biomedical Imaging Center, University of Fukui, Fukui, Japan, 4GE Healthcare, Calgary, Canada

Positron emission computed tomography (PET) is used for evaluating cerebral hemodynamic ischemic stages in patients with major cerebrovascular stenosis/occlusion for treatment indication. Using a rapid, low-resolution pre-scan method, arterial transit time (ATT) and corrected cerebral blood flow (CBF) could be obtained, even in the immediate clinical setting. This study aimed to clarify whether ATT is hemodynamically related to misery perfusion stratified with 15O-H2O/15O2-gas PET data. There was a significant correlation between ASL and PET CBF before and after ATT correction (r2=0.27, 0.55). ATT also significantly correlated with PET-OEF (r2=0.11) and is a useful parameter to classify cerebral ischemia.

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