Susceptometry-based oximetry is a well-established, robust method for quantifying hemoglobin oxygen saturation (HbO2) in vivo; but the method is somewhat limited by the orientation of the vessel of interest relative to Bo. T2-based oximetry, based on the dependence of blood water T2 on HbO2, provides greater flexibility with respect to vessel geometry. However, the measured T2 critically depends on Bo and sequence-specific imaging parameters. Here, a T2-prepared bSSFP sequence and appropriate calibration curve were used to extract HbO2 at the superior sagittal sinus and the results were compared to susceptometry-based oximetry. The agreement between both methods was excellent with 2% bias.
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