Meeting Banner
Abstract #4735

MRI submerging into The Big Blue: A comparative 3D-pCASL and IVIM-MRI brain perfusion study to elucidate circulatory adaptation during prolonged freediving

Vera Catharina Keil1, Lars Eichhorn2, Burkhard Mädler3, Jürgen Gieseke3, Frank Träber1, Wolfgang Block1, Martin Alois Sprinkart1, Andreas Müller1, Christine Schneider4, Lukas Scheef1, Hans Heinz Schild1, Dariusch Reza Hadizadeh1, and Elke Hattingen1

1Department of Radiology, University Hospital Bonn, Bonn, Germany, 2Department of Anesthesiology, University Hospital Bonn, Bonn, Germany, 3Clinical Science Department, Philips Healthcare, Germany, 4Department of Neurology, University Hospital Bonn, Bonn, Germany

Freedivers can endure severe hypoxemia during breathhold without any apparent neurological deficit. Little is known on how brain circulation adapts to deliberate breathhold. We examined 14 experienced freedivers during breathholds of 5 to 7.5 minutes at a 3T MRI applying 3D-pCASL and IVIM-MRI sequences to reveal dynamic alterations of cerebral blood flow (rCBF) and in order to elucidate the relationship of rCBF and perfusion fraction (PF) of IVIM-MRI. rCBF increased to 3.2-fold the baseline levels and negatively correlated to blood oxygen levels, but not to PF, which initially dropped during breathhold and therefore appears to represent another underlying physiological mechanism.

This abstract and the presentation materials are available to members only; a login is required.

Join Here