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Abstract #4737

Small vessel specific cerebrovascular reactivity with 7 tesla 2D Qflow MRI.

Lennart J. Geurts1, Alex Bhogal1, Jeroen C. W. Siero1,2, Geert Jan Biessels3, and Jaco J. M. Zwanenburg1

1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Spinoza Center for Neuroimaging, Amsterdam, Netherlands, 3Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, Netherlands

We aimed to measure cerebrovascular reactivity (CVR) specifically at the level of the superficial perforating arteries with 7T 2D Qflow, to develop a method to assess small vessel function for cerebral small vessel disease research. 7T 2D Qflow acquisitions through the semi oval center (CSO) and through the medial cerebral artery (M1) were acquired at baseline and during hypercapnia. CVRM1 corresponded to CVR values from Qflow literature and, while an order of magnitude smaller, CVRCSO corresponded to CVR values from ASL literature. This shows proof of concept that CVR of perforating arteries can be measured using 7T 2D Qflow.

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