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Abstract #4738

Segmented EPI readout Variable Flip-angle Magnetization Transfer (EP-vfMT) imaging for 7 T quantitative MT (qMT) Imaging

Se-Hong Oh1,2 and Mark J. Lowe1

1Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 2Department of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of

Because of the much higher SAR and longer acquisition time, patient studies using qMT at UHF have not been clinically feasible. In this work, we demonstrated a new approach (EP-vfMT) for whole brain 7T qMT data in a clinically reasonable time. EP-vfMT provides similar image quality to that obtained with conventional MT imaging, and shortens the scan time by utilizing segmented EPI readout and avoiding from SAR limitation. EP-vfMT generates qMT map in reasonable scan time and it exhibits similar myelin density distribution with qMT result from vdMT and aMWF map from ViSTa. Moreover, it maintains sensitivity to MS lesions.

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