Meeting Banner
Abstract #4741

ΔR1ρ, a potential indication for myelin concentration in white matter?

Ping Wang1, Richard Dortch1, and John C. Gore1

1Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Nashville, TN, United States

Previous studies have demonstrated that at high fields (3T and beyond), the difference of R between low and high spin-locking fields (ΔR) may reflect chemical exchange processes in biological tissues. This study aimed to investigate the possibility of using ΔR to assess the content of exchangeable protons in myelin in white matter by comparing ΔR with PSR (macromolecular to free pool size ratio from magnetization transfer imaging). The results show that ΔR and PSR have a much stronger correlation in white matter than in gray matter, inferring that ΔR might have a potential to evaluate myelin integrity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here