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Abstract #4742

Comparison of R1ρ dispersion in human brain between 3T and 7T

Ping Wang1, Henry Zhu1, and John C. Gore1

1Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Nashville, TN, United States

Previous studies have indicated that R (= 1/T) dispersion may be dominated by chemical exchange processes at higher fields, and the dispersion may be used to quantify exchange processes between water and labile protons, mainly amides and hydroxyls. At 3T some biological tissues with high macromolecular protein content may demonstrate a considerable dispersion, but fat and water rich tissues typically have a negligible R dispersion. In this study, we observed that the degree of R dispersion in white matter at 7T was more than three times the dispersion at 3T, confirming that chemical exchange is a major contribution to R and suggesting R dispersion at higher fields may help to characterize tissue physicochemical properties.

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