Although a few studies reported the possibility of Gd deposition in the brain by macrocyclic GBCAs, the final determination of deposition with macrocyclic GBCAs has not been performed. Because Synthetic MRI with MDME sequence enables quantitative measurements with relatively short time, our study aimed to investigate whether T1 relaxation time in globus pallidus was influenced by gadobutrol administrations by using the quantitative MR imaging. This study revealed that T1 shortening in globus pallidus occurs by gadobutrol administrations. Additional studies are needed to investigate the clinical significance of these findings.
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