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Abstract #4749

Glucose Tolerance Test in the Human Brain: 1H MRS study at 7 Tesla

Lana Galina Kaiser1, Ben Inglis2, Hirokazu Kawaguchi1, Masaki Fukunaga3, Norihiro Sadato3, and Tomohisa Okada4

1Diagnostics, Siemens Healthcare Japan, Tokyo, Japan, 2Psychology, UC Berkeley, Berkeley, CA, United States, 3NIPS, Okazaki, Japan, 4Department of Diagnostic Radiology, Kyoto University, Japan

The goal of this study is to perform an oral glucose tolerance test (GTT) in the healthy human brain tissue in vivo and to evaluate the performance of the recently developed 1H MRS technique. The observed glucose level curve shape showing increase and washout during the 1H MRS GTT test is consistent with the medical GTT blood measurements obtained in healthy subjects. This study demonstrates the initial steps towards better understanding of potential utility of 1H MRS in experiments on glucose metabolism in vivo in the context of nutrition, brain function, and various neurological disorders with impaired glucose utilization.

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