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Abstract #4750

Quantitative T1 mapping and somatotopic organization of the cerebellum at 7T : is there a link?

Yohan Boillat1, Pierre-Louis Bazin2, Rolf Gruetter1,3,4, and Wietske Van der Zwaag5,6

1Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Department of Radiology, University of Lausanne, Lausanne, Switzerland, 4Department of Radiology, University of Geneva, Geneva, Switzerland, 5Biomedical Imaging Research Center, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6Spinoza Centre for Neuroimaging, Amsterdam, Netherlands

In this study, the spatial relationship between the somatotopy and the pattern of myelination (as measured by quantitative T1-maps) in the cerebellum was investigated. Subject-specific surfaces were generated on which were mapped T1 values and somatotopic maps. Consistent somatotopic gradients organized through several lobules were present in the anterior and posterior lobes. Despite being more complex, changes of T1 values across the cerebellar surface were also observed and showed a similar orientation as the somatotopic organization. This study showed the potential structure-function relationship of the cerebellum observed at macroscale level.

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