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Abstract #4769

Validation of dMRI-Derived Fiber Orientations Using PLI in Human Fetal Hearts

Feng Yang1,2, YueMin Zhu2, Gabrielle Michalowicz3, Yves Usson3, Laurent Fanton2, Magalie Viallon2,4, Patrick Clarysse2, Pierre-Simon Jouk3, and Pierre Croisille2,4

1Department of Computer Science, School of Computer and Information Technology, Beijing Jiaotong University, Beijing, People's Republic of China, 2Univ.Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, F-69621, LYON, France, Villeurbanne, France, 3Equipe DYCTIM, Laboratoire TIMC-IMAG, UMR5525 CNRS, Université Grenoble Alpes, La Tronche, France, France, 4Jean-Monnet University, Saint-Etienne, France, Saint-Etienne, France

To validate to what extent the fiber orientations derived from diffusion MRI (dMRI) reveal anatomical reality, polarized light imaging (PLI) allowing the fiber orientations of the human heart to be physically measured with high spatial resolution was used. The dMRI and PLI orientation measurements of the same hearts are then compared using a multimodal registration-based framework. Experimental results show that dMRI and PLI have similar variation patterns of elevation or azimuth angles, except that dMRI introduced a decrease of about 24º in transmural elevation angle range. No significant differences were observed on azimuth angle in both modalities.

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