Abstract #4806

Non-invasive placental perfusion imaging in pregnancies complicated by fetal heart disease using velocity-selective arterial spin labeling

Zungho Zun^1,2,3, Greg Zaharchuk⁴, Nickie Niforatos-Andescavage^1,2, Samantha Bauer¹, Mary T Donofrio^2,3,5, and Catherine Limperopoulos^1,2,3

¹Division of Diagnostic Imaging and Radiology, Children’s National Medical Center, Washington, DC, United States, ²Division of Fetal and Transitional Medicine, Children’s National Medical Center, Washington, DC, United States, ³Departments of Radiology and Pediatrics, George Washington University, Washington, DC, United States, ⁴Department of Radiology, Stanford University, Stanford, CA, United States, ⁵Division of Cardiology, Children’s National Medical Center, Washington, DC, United States

Recent data have reported that placental dysfunction may be present in the setting of complex fetal congenital heart disease (CHD). We performed placental perfusion imaging using velocity-selective arterial spin labeling in pregnancies complicated by fetal CHD and healthy pregnancies. We demonstrated that global placental perfusion and regional variation of perfusion were significantly correlated with GA in pregnancies complicated by fetal CHD, but not in healthy controls. Our findings suggest that placental ASL may have the potential to serve as an early biomarker of placental dysfunction in fetal CHD.

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