Abstract #4807

Measuring human placental blood flow with multi-delay 3D GRASE pseudo-continuous arterial spin labeling at 3 Tesla

Xingfeng Shao¹, Dapeng Liu², Thomas Martin², Teresa Chanlaw³, Sherin U. Devaskar³, Carla Janzen⁴, Daniel Margolis², Kyunghyun Sung², and Danny JJ Wang¹

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ³Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁴Department of Obstetrics and Gynecology, Division of Perinatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

We presented a multi-delay pCASL combined with inner-volume GRASE imaging technique to measure placental blood flow (PBF) and arterial transit time (ATT) simultaneously, and report PBF and ATT evolution along different gestational ages during the second trimester. More blood flew through placenta with a slightly shorter transit time was seen with fetal development. Overall, PBF and ATT for the second trimester were 129.8±44.7 ml/min/100g and 786.8±174.1 ms respectively.

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