Abstract #4812

Ferumoxytol MRA in the Pregnant Rhesus Macaque

Jacob Macdonald¹, Philip Corrado¹, Sydney Nguyen², Christopher J Francois³, Scott Reeder^1,3,4,5,6, Ian Bird², Dinesh Shah⁷, Thaddeus G Golos^2,7,8, Oliver Wieben^1,3, and Kevin M Johnson^1,3

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, ³Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁷Obstetrics and Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁸Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States

Both maternal and fetal complications arise from poor vascular adaptation to pregnancy. Assessing utero-placental vessels with contrast-enhanced MR Angiography may be valuable, but Gadolinium based contrast agents commonly used for MR angiography are contraindicated during pregnancy. In this work, we tested the feasibility of ultrashort echo time contrast-enhanced angiography with Ferumoxytol in a small cohort of pregnant rhesus macaques. Ferumoxytol allowed for detailed visualization of utero-placental vessels without detectable uptake in fetal tissues.

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