Developmental abnormalities in placental vascular formation are associated with major complications of pregnancy, such as fetal growth restriction and early onset pre-eclampsia. Multi-shell diffusion MRI at 3T has been shown to be capable of capturing fine microstructural information in a wide variety of organs and disease states, and could prove valuable for studying the human placenta in-vivo. We develop a rich scanning protocol, and use the data to investigate the complexity of models supported by the placental diffusion MRI signal. We demonstrate the feasibility of using this non-invasive approach to quantify microstructure in the human placenta and surrounding tissue.
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