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Abstract #4833

Comparison of diffusion imaging microstructure models of the human placenta at 3T

Paddy J. Slator1, Jana Hutter2,3, Laura McCabe2, Ana Dos Santos Gomes2, Anthony N. Price2,3, Mary A. Rutherford2, Joseph V. Hajnal2,3, and Daniel C. Alexander1

1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 2Centre for the Developing Brain, King's College London, London, United Kingdom, 3Biomedical Engineering Department, Division of Imaging Sciences, King's College London, London, United Kingdom

Developmental abnormalities in placental vascular formation are associated with major complications of pregnancy, such as fetal growth restriction and early onset pre-eclampsia. Multi-shell diffusion MRI at 3T has been shown to be capable of capturing fine microstructural information in a wide variety of organs and disease states, and could prove valuable for studying the human placenta in-vivo. We develop a rich scanning protocol, and use the data to investigate the complexity of models supported­­ by the placental diffusion MRI signal. We demonstrate the feasibility of using this non-invasive approach to quantify microstructure in the human placenta and surrounding tissue.

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