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Abstract #4834

Quantitative Assessment of Markers of Oxidative Stress in Mice Model of Renal Artery Stenosis

Behzad Ebrahimi1,2, Alvin Ihsani2, Arkadiusz Sitek2, Slobodan I Macura3, and Lilach O Lerman1

1Nephrology, Mayo Clinic, Rochester, MN, United States, 2Radiology, Harvard/MGH, Boston, MA, United States, 3Biochemistry and Molecular Biology, Mayo Clinic

Inability of cells to detoxify reactive oxidative species (ROS) is responsible for numerous degenerative pathological conditions. Currently there is no clinical method to assess reduction-oxidation (redox) state in vivo. In this study, using a cyclic nitroxide T1 MR probe with unique characteristics, we propose a two-tissue compartment model which provides quantitative information of markers of oxidative stress. Results demonstrated the feasibility of redox status assessment in vitro and in vivo in the stenotic mouse kidney. In the stenotic kidney, our method indicated increased renal ROS production, accompanied by preserved ability to detoxify ROS compared to the contralateral kidney.

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