Inability of cells to detoxify reactive oxidative species (ROS) is responsible for numerous degenerative pathological conditions. Currently there is no clinical method to assess reduction-oxidation (redox) state in vivo. In this study, using a cyclic nitroxide T1 MR probe with unique characteristics, we propose a two-tissue compartment model which provides quantitative information of markers of oxidative stress. Results demonstrated the feasibility of redox status assessment in vitro and in vivo in the stenotic mouse kidney. In the stenotic kidney, our method indicated increased renal ROS production, accompanied by preserved ability to detoxify ROS compared to the contralateral kidney.
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