In this study, we investigated the placenta anatomy and function in a mouse model of intrauterine inflammation, using T2-weighted MRI and introvoxel incoherent motion (IVIM) MRI to measure placental perfusion. The high-resolution T2-weighted images demonstrated altered placenta anatomy in response to the acute inflammatory injury, which agreed with the histological measurements. IVIM of the mouse placenta was acquired with diffusion-weighted echo-planar imaging in a reduced field-of-view. The pseudo-diffusion fraction (f) and coefficient (D*) fitted from IVIM model indicated reduced perfusion volume (f) and velocity (f·D*) in the injured placentas compared to the shams.
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