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Abstract #4870

Multi-parametric MRI of Murine Unilateral Ureter Obstruction

Feng Wang1,2, Keiko Takahashi3, Hua Li1, Zhongliang Zu1,2, Junzhong Xu1,2, Raymond C. Harris3, Takamune Takahashi3, and John C. Gore1,2

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3Division of Nephrology and Hypertension, Vanderbilt University, Nashville, TN, United States

Multi-parametric MRI techniques may allow the assessment of renal injury and function in a sensitive and objective manner. This study aimed to evaluate an array of MRI methods that exploit endogenous contrasts for their sensitivity in detecting abnormal features associated with kidney disease in a murine model of unilateral ureter obstruction (UUO). Diffusion weighted imaging (DWI), quantitative magnetization transfer (qMT), chemical exchange saturation transfer (CEST), and nuclear Overhauser enhancement (NOE) provide specific information about the cellular and molecular changes produced by UUO.

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