Abstract #4871

Assessment of Renal Fibrosis in Murine Diabetic Nephropathy Using Quantitative Magnetization Transfer MRI

Feng Wang^1,2, Daisuke Katagiri³, Ke Li¹, Shinya Nagasaka³, Hua Li¹, Keiko Takahashi³, Suwan Wang³, C. Chad Quarles^1,2, Ming-Zhi Zhang³, Raymond C. Harris³, John C. Gore^1,2, and Takamune Takahashi³

¹Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ²Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ³Division of Nephrology and Hypertension, Vanderbilt University, Nashville, TN, United States

Current clinical tests are insufficient for non-invasively assessing renal fibrosis. Here we evaluated the utility of high-resolution quantitative magnetization transfer (qMT) MRI to detect renal fibrosis using a murine model of progressive DN and compared the results with histological analyses. Our results show that high-resolution qMT could provide an index to reveal renal cortical fibrosis.

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