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Abstract #4871

Assessment of Renal Fibrosis in Murine Diabetic Nephropathy Using Quantitative Magnetization Transfer MRI

Feng Wang1,2, Daisuke Katagiri3, Ke Li1, Shinya Nagasaka3, Hua Li1, Keiko Takahashi3, Suwan Wang3, C. Chad Quarles1,2, Ming-Zhi Zhang3, Raymond C. Harris3, John C. Gore1,2, and Takamune Takahashi3

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3Division of Nephrology and Hypertension, Vanderbilt University, Nashville, TN, United States

Current clinical tests are insufficient for non-invasively assessing renal fibrosis. Here we evaluated the utility of high-resolution quantitative magnetization transfer (qMT) MRI to detect renal fibrosis using a murine model of progressive DN and compared the results with histological analyses. Our results show that high-resolution qMT could provide an index to reveal renal cortical fibrosis.

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