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Abstract #4872

Reversible Changes in Cardiac Function and Metabolism in an Inducible Mouse Model of Type 1 Diabetes

Dragana Savic1, Maria Rohm, Vicky Ball, Mary Kate Curtis, Lisa Heather, Frances M Ashcroft, and Damian J. Tyler

1University of Oxford, Oxford, United Kingdom

Heart disease is the leading cause of death in Type 1 diabetic patients, however the mechanistic link has not been fully established. In this study an inducible and reversible mouse model of Type 1 diabetes was used. Depression of cardiac function and the increase in blood glucose occur in combination with suppression of pyruvate to bicarbonate conversion. By reversing diabetes with Glibenclamide, cardiac function and blood glucose concentration was restored. This study demonstrated changes that occur alongside the development of a reversible model of Type 1 diabetes and how the action of Glibenclamide can affect metabolism and function of the heart.

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