Abstract #4874

Repeatability and User Variability of Myocardial Tissue Phase Mapping in Mice

Nivedita K. Naresh¹, Cynthia Yang¹, Sol Misener¹, Bradley D. Allen¹, Michael Markl^1,2, James C. Carr^1,3,4, and Daniele Procissi¹

¹Radiology, Northwestern University, Chicago, IL, United States, ²Biomedical Engineering, Northwestern University, Chicago, IL, United States, ³Medicine, Northwestern University, Chicago, IL, United States, ⁴McCormick School of Engineering, Northwestern University, Chicago, IL, United States

Mouse models can help investigate the molecular mechanisms underlying complex cardiovascular diseases. Assessment of myocardial regional wall motion plays a very important role in the diagnosis and management of several cardiovascular diseases and can be linked to many underlying biological processes. In this study, we evaluated the repeatability and inter-user variability of the myocardial tissue phase mapping method in mice. We found that myocardial tissue phase mapping can be performed with good repeatability and little user variability in mice to reliably quantify both global and regional myocardial velocities.

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