Abstract #4875

MRI/PET of Myocardial Extracellular Volume in a Canine model of Chemotherapy

Chia-Ying Liu¹, Cynthia Davies-Venn¹, Comfort Elumogo¹, Rolf Symons¹, Victoria Hoffmann², Kelly Rice², Roberto Maass-Moreno¹, Veit Sandfort¹, Stefan Zimmermann³, Amir Pourmorteza¹, Mark Ahlman¹, and David Bluemke¹

¹Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ²Division of Veterinary Resources, National Institutes of Health, ³Department of Radiology, Johns Hopkins Hospital, MD, United States

We used simultaneous MR/FDG PET to measure the myocardial extracellular volume (ECV) and glucose metabolism (estimated by standard uptake value, SUV) in a canine model of chemotherapy (ChT); comparison was made to ECV in relationship to a myocardial infarct (MI) models. MRI ECV in the ChT group was elevated by 16% and 23% compared to the MI group in the remote and adjacent myocardial segments, respectively. PET SUV in the ChT group was reduced by 49% and 41% compared to the MI group in the remote and adjacent myocardial segments, respectively. Difference was also observed in the MRI partition coefficient but not in the native T1.

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