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Abstract #4876

Evaluation of the impact of strain correction on the secondary eigenvector of diffusion with in vivo and ex vivo porcine hearts

Pedro Ferreira1, Sonia Nielles-Vallespin2, Ranil de Silva1, Andrew Scott1, Daniel Ennis3, Daniel Auger4, Jonathan Suever5, Xiaodong Zhong6, Bruce Spottiswoode7, Dudley Pennell1, Andrew Arai2, and David Firmin1

1Cardiovascular BRU, Royal Brompton Hospital, London, United Kingdom, 2NHLBI, National Institutes of Health, MD, United States, 3Department of Radiological Sciences, UCLA, CA, United States, 4Biomedical Engineering, University of Virginia, VA, United States, 5Geisinger Medical Center, PA, United States, 6Siemens Healthcare, GA, United States, 7Siemens Healthcare, TN, United States

Myocytes have a laminar organization, where sheets of myocytes interleave with collagen-lined shear layers. Cardiac diffusion tensor imaging is capable of probing sheet dynamics with secondary diffusion directions, although questions remain about cardiac strain being a possible confounder. Here we study the validity of strain-correcting cardiac diffusion tensor data by directly comparing in vivo DTI data without and with strain correction, to ex vivo DTI data of the same porcine hearts arrested in a diastolic or systolic conformation. Results show that the current strain correction model exaggerates the contribution of microscopic strain to diffusion resulting in an over-correction.

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