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Abstract #4877

Simultaneous Cardiac and Renal oblique-slice T1-Mapping Differentiates Contrast Agent Activity in Normal and Doxorubicin-treated Rats

Ronald J Beyers1, Dean Schwartz2, Tessa Hutchinson3, Meghan Ward3, Nouha Salibi1,4, Christian Goldsmith3, and Thomas Denney1

1MRI Research Center, Auburn University, Auburn, AL, United States, 2Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, United States, 3Department of Chemistry and Biochemistry, Auburn University, Auburn, AL, United States, 4MR R&D, Siemens Healthcare, Malvern, PA, United States

We developed a cardiac multi-oblique-slice T1-mapping sequence, called Tmax, for simultaneous in vivo cardiac and multi-region T1-mapping in rats. We validated Tmax with gadolinium contrast agent (CA) scans then applied it to support our concurrent development of a reactive oxygen species activated T1-shortening agent, called H4qtp2, in doxorubicin-treated (Dox) rats. The new Tmax sequence performed excellent at simultaneously quantifying gadolinium T1 effects in cardiac and renal regions. However, application of Tmax with low dose levels of H4qtp2 CA in Dox rats gave marginal results from too low dose of H4qtp2 to sufficiently affect the T1 and quantify Dox-induced pathology

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