Abstract #4879

Feasibility of 4D-Flow Imaging of Uterine Blood Flow in the Pregnant Rhesus Macaque

Philip Corrado¹, Jacob Macdonald¹, Sydney Nguyen², Kevin Johnson¹, Chris Francois³, Ronald R. Magness⁴, Scott B. Reeder^1,3,5,6,7, Ian Bird⁸, Dinesh Shah⁸, Thaddeus G. Golos^8,9, and Oliver Wieben^1,3

¹Medical Physics, University of Wisconsin Madison, Madison, WI, United States, ²Endocrinology & Reproductive Physiology, University of Wisconsin Madison, Madison, WI, United States, ³Radiology, University of Wisconsin Madison, Madison, WI, United States, ⁴Obstetrics & Gynecology, University of South Florida, Tampa, FL, United States, ⁵Biomedical Engineering, University of Wisconsin Madison, ⁶Medicine, University of Wisconsin Madison, ⁷Emergency Medicine, University of Wisconsin Madison, ⁸Obstetrics & Gynecology, University of Wisconsin Madison, Madison, WI, United States, ⁹Comparative Biosciences, University of Wisconsin Madison, Madison, WI, United States

4D-Flow MRI is introduced as an alternative to Doppler velocimetry in monitoring blood flow to the placenta in pregnancy. Our 3D radially undersampled PC-VIPR technique provided volumetric coverage of uterus and relevant vasculature with a 10-minute scan. Uterine arteries and ovarian veins were visualized in a 0.83mm isotropic resolution angiogram and flow rates and vessel sizes were measured retrospectively. Repeated scans of four rhesus macaques on subsequent days showed reproducibility of flow rate and cross sectional area measurements in vessels of interest, demonstrating the potential for 4D-Flow MRI for assessing utero-placental vascular health.

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