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Abstract #4880

4D flow MRI measurements in ex vivo beating pig hearts as a testing platform for transcathether aortic valve implantation

Eva S Peper1, Alberto Leopaldi2, Sjoerd van Tuijl2, Nicky de Jonge2, Gustav J Strijkers3, Arend de Weger4, Aart J Nederveen1, Henk A Marquering3, and Pim van Ooij1

1Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 2LifeTec Group, Eindhoven, the Netherlands, Netherlands, 3Department of Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands, 4Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands

In this 4D flow MRI study, ex vivo beating pig heart models in an MR-compatible setup mimicking human physiological conditions were used to investigate flow alterations after implantation of artificial valves designed for transcathether aortic valve implantations (TAVI). Two pig hearts had implanted TAVI valves (one with and one without attachment to the aortic sinuses) and were compared to five pig hearts without valve implantation. For both pig hearts with implanted valves, substantial aortic backflow, and thus paravalvular leakage, was observed. The ex vivo set-up presented is thus suitable for cardiac flow experiments.

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