Abstract #4880

4D flow MRI measurements in ex vivo beating pig hearts as a testing platform for transcathether aortic valve implantation

Eva S Peper¹, Alberto Leopaldi², Sjoerd van Tuijl², Nicky de Jonge², Gustav J Strijkers³, Arend de Weger⁴, Aart J Nederveen¹, Henk A Marquering³, and Pim van Ooij¹

¹Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, ²LifeTec Group, Eindhoven, the Netherlands, Netherlands, ³Department of Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands, ⁴Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands

In this 4D flow MRI study, ex vivo beating pig heart models in an MR-compatible setup mimicking human physiological conditions were used to investigate flow alterations after implantation of artificial valves designed for transcathether aortic valve implantations (TAVI). Two pig hearts had implanted TAVI valves (one with and one without attachment to the aortic sinuses) and were compared to five pig hearts without valve implantation. For both pig hearts with implanted valves, substantial aortic backflow, and thus paravalvular leakage, was observed. The ex vivo set-up presented is thus suitable for cardiac flow experiments.

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