Abstract #4885

Cardiac Magnetic Resonance for Characterizing a Spontaneous Hypertrophic Cardiomyopathy Mouse Model

Min-Chi Ku¹, Till Huelnhagen¹, Andreas Pohlmann¹, and Thoralf Niendorf^1,2,3

¹Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²Experimental and Clinical Research Center, Charite Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ³DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany

HCM is the most common inherited heart disease. The two most frequently seen mutated genes are MYH7 and MYBPC3 which account for nearly 80% of familiar HCM. In this study we hypothesized that these gene variants will affect both LV and RV function. By in-vivo CMR we detected LV hypertrophy in a mouse strain DBA/2J bearing the two gene variants. Interestingly there is no defected LV function found but changes in RV function as both male and female DBA/2J mice had declined RVEF. Our results provide new insights into the correlation of genetic alteration and HCM phenotype.

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