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Abstract #4886

4D Cine Strategy for Assessment of Mouse Cardiac Function and Infarct Size in a Single Acquisition Optimized for a Clinical 3T MR System

Lindsey A Crowe1, Fabrizo Montecucco2, Federico Carbone2, Iris Friedli1, Anne-Lise Hachulla1, Vincent Braunersreuther3, Francois Mach3, and Jean-Paul Vallée1

1Department of Radiology, Geneva University Hospitals, Geneva, Switzerland, 2Department of Internal Medicine, University of Genoa, Italy, 3Department of Cardiology, Geneva University Hospitals, Geneva, Switzerland

Small cardiac imaging on clinical 3T machines is an important, cost effective translational step for new contrast media and sequence validation. We developed for the first time a new 4D strategy tailored for 3T to simultaneously assess function and infarct in mice, validated against 2D cine, post mortem and histology. Isotropic 3D cardiac cine of mice on a clinical 3T system improved coverage and reduced flow artifacts with higher spatial and temporal resolution for more accurate quantification of cardiac function. Infarct volume enhancement was quantifiable from the same 3D cine acquisition.

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