Small cardiac imaging on clinical 3T machines is an important, cost effective translational step for new contrast media and sequence validation. We developed for the first time a new 4D strategy tailored for 3T to simultaneously assess function and infarct in mice, validated against 2D cine, post mortem and histology. Isotropic 3D cardiac cine of mice on a clinical 3T system improved coverage and reduced flow artifacts with higher spatial and temporal resolution for more accurate quantification of cardiac function. Infarct volume enhancement was quantifiable from the same 3D cine acquisition.
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