Abstract #4887

Gadobutrol- vs. gadoterate meglumine-enhanced multi-phase 3D-MRA and 4D-MRA at 1.5T and 3T: an intra-individual quantitative and qualitative comparison of macrocyclic contrast agents in minipigs

Dariusch Reza Hadizadeh¹, Gregor Jost², Vera Catharina Keil¹, Christian Marx¹, Maximilian Rauch¹, Frederic Carsten Schmeel¹, Hubertus Pietsch², Hans Heinz Schild¹, and Winfried Albert Willinek³

¹Radiology, University of Bonn, Bonn, Germany, ²MR and CT Contrast Media Research, Bayer Pharma AG, Berlin, Germany, ³Zentrum für Radiologie, Neuroradiologie, Sonographie und Nuklearmedizin, Krankenhaus der barmherzigen Brüder, Trier, Germany

In an animal model bolus kinetics and image quality of the macrocyclic contrast agents (CA) gadobutrol (standard and half-dose) and gadoterate meglumine (standard-dose) were investigated intra-individually in multi-phase 3D- (MP3D) MRA and in 4D-MRA at 1.5T and 3T. Standard dose gadobutrol provided significantly higher signals in both MP3D- and 4D-MRA at both field strengths. Differences were most prominent in venous imaging phases. At 3T, arterial first pass peaks were truncated in 7/8 minipigs using standard dose CA. Image quality analysis of MP3D confirmed higher image quality in venous phases with standard-dose gadobutrol compared to gadoterate meglumine at both field strengths.

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