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Abstract #4889

Multiparametric CMR protocol and analysis methods for the detection of early cardiotoxicity remodelling in the mini-swine.

Delphine Perie1, Clémence Balosetti1, Hélène Héon2, Nagib Dahdah3, Farida Cheriet1, Matthias Friedrich4, and Daniel Curnier5

1Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Research Center, CHUM, Montreal, QC, Canada, 3Pediatric cardiology, CHU Sainte-Justine, Montreal, QC, Canada, 4Health Center, McGill University, Montreal, QC, Canada, 5Kinesiology, Université de Montréal, Montreal, QC, Canada

Some Cardiovascular magnetic resonance (CMR) studies investigated the long term effects of cancer treatments, but were never applied to the detection of early changes during cardiotoxicity remodelling. The CMR parameters we investigated in the miniature swine therapeutic model with doxorobucin was able discriminate treated animals from controls. Differences were detectible earlier than onset of classical echocardiographic changes. Translating these observations to personalized medicine approach could be the premise for the oncologist to know accurately when the treatment just starts to have deleterious effect on myocardium instead of just observing that the heart was damaged by doxorubicin.

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