Abstract #4889

Multiparametric CMR protocol and analysis methods for the detection of early cardiotoxicity remodelling in the mini-swine.

Delphine Perie¹, Clémence Balosetti¹, Hélène Héon², Nagib Dahdah³, Farida Cheriet¹, Matthias Friedrich⁴, and Daniel Curnier⁵

¹Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ²Research Center, CHUM, Montreal, QC, Canada, ³Pediatric cardiology, CHU Sainte-Justine, Montreal, QC, Canada, ⁴Health Center, McGill University, Montreal, QC, Canada, ⁵Kinesiology, Université de Montréal, Montreal, QC, Canada

Some Cardiovascular magnetic resonance (CMR) studies investigated the long term effects of cancer treatments, but were never applied to the detection of early changes during cardiotoxicity remodelling. The CMR parameters we investigated in the miniature swine therapeutic model with doxorobucin was able discriminate treated animals from controls. Differences were detectible earlier than onset of classical echocardiographic changes. Translating these observations to personalized medicine approach could be the premise for the oncologist to know accurately when the treatment just starts to have deleterious effect on myocardium instead of just observing that the heart was damaged by doxorubicin.

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