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Abstract #4890

A spontaneous type 2 diabetic rhesus monkey model for cardiac MR study

Yu Zhang1, Jie Zheng2, and Fabao Gao3

1West China Hospital, Sichuan University, Chengdu, People's Republic of China, 2Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, 3West China HospitaL, Sichuan University, Chengdu

The aim of this study was to provide a human-like diabetic monkey model for cardiovascular research. Myocardial function and tissue characterizations were measured by CMR in 14 diabetic and 5 control monkeys. In addition to diastolic dysfunction, minor and moderate diffuse fibrosis was shown in cardiac T1, T1r, ECV, and non-contrast fibrosis index images in all the hearts of all diabetic monkeys, confirmed by histopathology finding in one diabetic monkey.

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