Abstract #4891

Early Prediction of Chronic Infarct Size by Acute Strain: A Cardiac MRI Study of Myocardial Infarction in Pigs

Sarayu Parimal¹, Smita Sampath¹, Ibrahim Mazlan^2,3, Grace Croft^2,3, Teresa Totman^2,3, Yvonne Tay Wei Zheng⁴, Elaine Manigbas⁴, Michael Klimas⁵, Jeffrey L. Evelhoch⁵, Dominique P.V. Kleijn^2,3, and Chih-Liang Chin¹

¹Translational Biomarkers, Merck Sharp & Dohme, Singapore, Singapore, ²Cardiovascular Research Institute, National University Heart Centre, Singapore, ³Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, ⁴Comparative Medicine Imaging Facility, Center for Life Sciences, National University of Singapore, Singapore, ⁵Translational Biomarkers, Merck & Co., Inc., West Point, PA, United States

We characterized cardiac structure and function longitudinally in myocardial infarcted pigs, induced by permanent ligation of left circumflex artery of left ventricle (LV), to identify early strain biomarkers that are predictive of late stage remodeling. Pigs were imaged pre- and post-surgery at 1-wk and 4-wk. Reduction of percentage of infarct was observed at basal antero-lateral and mid infero-lateral regions at 4-wk post-surgery. Decreased peak circumferential strain was observed at infarcted areas showing compromised contractility. In addition, ROC analyses revealed that acute strain at 1-wk and early strain change from baseline can predict chronic infarct size suggesting that LV strain could potentially serve as early biomarker for novel therapies.

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