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Abstract #4892

Aortic Wall MR Imaging for Assessing Rosuvastatin Therapy in Atherosclerotic Animal Model

Juan Huang1, Yan Song , Mingmei Li, Xiaotao Deng, Sheng Jiao, Jingying Yu, Min Chen, and Xiaoqi Wang

1Beijing Hospital, Beijing, People's Republic of China

Here we present the high-resolution MRI imaging for assessing therapy of titrated rosuvastatin for atherosclerosis in rabbit models. This study shows that abdominal aorta wall in both control and treated rabbits get thicker with prolonged continuous feeding of cholesterol, aortic plaques grows bigger with this progression. The MRI vascular wall imaging measured atherosclerotic plaques with well correlation of histological classifications. Statical regression showed that the group with rosuvastatin treatment reduced the aortic plaques comparing to the control rabbits.

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