Abstract #4894

Comparison of Differentiation Capability among CEST Imaging, DWI and FDG-PET/CT in Patients with Pulmonary Lesions

Yoshiharu Ohno^1,2, Masao Yui³, Mitsue Miyazaki⁴, Yuji Kishida⁵, Sinichiro Seki^1,2, Katsusuke Kyotani⁶, and Takeshi Yoshikawa^1,2

¹Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan, ³Center for Medical Research and Development, Toshiba Medical Systems Corporation, Otawara, Japan, ⁴MR Research, Toshiba Medical Research Institute USA, Vernon Hills, IL, United States, ⁵Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan

Chemical exchange saturation transfer (CEST) imaging is suggested as a new technique for MR-based molecular imaging techniques in vivo and in vitro studies. We hypothesized that newly developed CEST imaging may have a similar potential for differentiating malignant from benign pulmonary nodules and masses, when compared with DWI and FDG-PET/CT. The purpose of this study was to directly and prospectively compare the differentiation capability among CEST imaging, DWI and FDG-PET/CT in patients with pulmonary lesions.

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