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Abstract #4896

Asthma Ventilation Abnormalities Measured using Fourier-Decomposition Free-breathing Pulmonary 1H MRI

Dante PI Capaldi1, Khadija Sheikh1, Rachel L Eddy1, Sarah Svenningsen1, Miranda Kirby2, David G McCormack3, Grace Parraga1, and Canadian Respiratory Research Network

1Robarts Research Institute, London, ON, Canada, 2Centre for Heart Lung Innovation, Vancouver, ON, Canada, 3Division of Respirology, University of Western Ontario, London, ON, Canada

Hyperpolarized noble-gas-MRI provides a way to visualize and regionally measure ventilation-heterogeneity in asthma, which has been shown to be sensitive to treatment response. Fourier-decomposition of free-breathing 1H MRI (FDMRI) has been proposed as an alternative way to evaluate regional-ventilation without the need for exogenous contrast. We hypothesized that ventilation-abnormalities would be qualitatively and quantitatively similar between the two imaging methods, and hence our objective was to measure ventilation-defects using FDMRI in asthma patients for comparison with inhaled-gas-MRI. Preliminary results in asthma showed that FDMRI ventilation-abnormalities were related to hyperpolarized noble-gas-MRI and clinical measurements of ventilation-heterogeneity in severe-asthmatics.

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