Hyperpolarized noble-gas-MRI provides a way to visualize and regionally measure ventilation-heterogeneity in asthma, which has been shown to be sensitive to treatment response. Fourier-decomposition of free-breathing 1H MRI (FDMRI) has been proposed as an alternative way to evaluate regional-ventilation without the need for exogenous contrast. We hypothesized that ventilation-abnormalities would be qualitatively and quantitatively similar between the two imaging methods, and hence our objective was to measure ventilation-defects using FDMRI in asthma patients for comparison with inhaled-gas-MRI. Preliminary results in asthma showed that FDMRI ventilation-abnormalities were related to hyperpolarized noble-gas-MRI and clinical measurements of ventilation-heterogeneity in severe-asthmatics.
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