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Abstract #4900

Impact of Helium-Oxygen Inhalation on Aerosol Deposition in Asthmatic Rats using UTE-MRI

Hongchen Wang1, Felicia Julea1, Georges Willoquet1, Catherine Sebrié1, Sébastien Judé2, Anne Maurin2, Stéphanie Rétif3, Sharuja Natkunarajah3, Stéphanie Lerondel3, Rose-Marie Dubuisson1, Luc Darrasse1, Geneviève Guillot1, Ludovic de Rochefort1, and Xavier Maître1

1Imagerie par Résonance Magnétique Médicale et Multi-Modalités (UMR8081) IR4M, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France, 2Centre de Recherches Biologiques, CERB, Baugy, France, 3Centre d'Imagerie du Petit Animal CIPA, PHENOMIN-TAAM UPS44, CNRS, Orléans, France

Asthma is a worldwide chronic respiratory disease. The common treatment by inhaled therapy needs quantitative imaging approaches to understand the impact of carrier gas on aerosol deposition. 3D UTE-MRI combined with aerosolized Gd-DOTA was applied onto spontaneous breathing and mechanically ventilated asthmatic animals. Here, administration and imaging protocols were developed to ventilate and nebulize control and asthmatic rats in order to compare the resulting aerosol distribution with two carrier gas mixtures: air and helium-oxygen.

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