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Abstract #4901

Evaluation of Regional Lung Function in Interstitial Lung Disease with Hyperpolarized Xenon-129 Lung 3D SB-CSI

Jaime Mata1, Kun Qing1, Nicholas Tustison1, Tallisa Altes1,2, John Mugler1, Michael Shim1, Lucia Flors1, Grady Miller1, and Borna Mehrad1

1University of Virginia, Charlottesville, VA, United States, 2University of Missouri, MO, United States

3D Single-Breath Chemical Shift Imaging (3D SB-CSI) is capable of non-invasively assessing regional lung ventilation and gas uptake/exchange within a single breath-hold, typically less than 10 seconds. From this study, we present preliminary clinical results of 3D SB-CSI from healthy and interstitial lungdisease (ILD) subjects. Having novel information on regional changes in ventilation and gas uptake/exchange allows for a better understanding of lung physiology, disease progression, and treatment efficacy.

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