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Abstract #4911

Detecting Differences in Parenchymal and Vascular Oxygenation in the Lungs with Quantitative Susceptibility Mapping

Teckla G Akinyi1,2, Jinbang Guo1,3, Jason C Woods1,3, Chunlei Liu4, Luke Xie, and Zackary I Cleveland1,2

1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Department of Physics, Washington University, Saint Louis, MO, United States, 4Electrical Engineering and Computer Sciences, University of California -Berkeley, Berkeley, CA, United States

Quantitative susceptibility (QSM) mapping measures the spatial distribution of magnetic susceptibility, and is thus sensitive to the chemical and microstructure properties of tissues. Here we have combined QSM with multi-echo, radial ultra-short echo-time (UTE) MRI to assess regional variations in lung susceptibility in mice. We demonstrate QSM can differentiate between lung parenchyma, which is paramagnetic due to the presence of molecular O2 and pulmonary vasculature which is diamagnetic. Moreover, we demonstrated that the susceptibility differences between these two lung regions increases with increased oxygen partial pressure, demonstrating the approach’s sensitivity to regional pulmonary function.

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