Abstract #4912

Quantification of regional lung ventilation in COPD patients: Validation of ventilation-weighted Fourier decomposition-MRI with dynamic fluorinated gas MRI and lung function testing.

Till Frederik Kaireit^1,2, Marcel Gutberlet^1,2, Andreas Voskrebenzev^1,2, Julia Freise³, Tobias Welte³, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Clinic of Pneumology, Hannover Medical School, Hannover, Germany

Quantification of regional lung ventilation is of high relevance for lung diseases like chronic obstructive lung disease (COPD) or asthma. Regional ventilation of the lungs in COPD patients was assessed using ventilation-weighted Fourier decomposition-MRI and validated with real-time dynamic fluorinated MRI and lung function test. Strong correlations were found comparing both techniques with each other and with lung function testing which is used for COPD classification.

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