Abstract #4913

Development and comparison of 19F and hyperpolarized 129Xe lung MRI for preclinical application in mice

Alexandre A Khrapitchev¹, Rohan S Virgincar^1,2, James R Larkin¹, Niloufar Zarghami¹, Sheena Wallington¹, Ana L Gomes¹, Stuart Gilchrist¹, Paul Kinchesh¹, Sean Smart¹, and Nicola R Sibson¹

¹CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, ²Biomedical Engineering, Duke University, Durham, NC, United States

The ¹⁹F approach is easier and cheaper to implement than the hyperpolarized gas setup and is immediately applicable to a range of pre-clinical work. However, ¹²⁹Xe MRI provides a unique dynamic tool that may have important applications warranting the additional effort and cost involved. We have compared lung ¹⁹F MRI with hyperpolarized ¹²⁹Xe MRI, in both cases using an Ultra Short Echo (UTE) sequence on a 7.0T preclinical spectrometer.

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