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Abstract #4913

Development and comparison of 19F and hyperpolarized 129Xe lung MRI for preclinical application in mice

Alexandre A Khrapitchev1, Rohan S Virgincar1,2, James R Larkin1, Niloufar Zarghami1, Sheena Wallington1, Ana L Gomes1, Stuart Gilchrist1, Paul Kinchesh1, Sean Smart1, and Nicola R Sibson1

1CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 2Biomedical Engineering, Duke University, Durham, NC, United States

The 19F approach is easier and cheaper to implement than the hyperpolarized gas setup and is immediately applicable to a range of pre-clinical work. However, 129Xe MRI provides a unique dynamic tool that may have important applications warranting the additional effort and cost involved. We have compared lung 19F MRI with hyperpolarized 129Xe MRI, in both cases using an Ultra Short Echo (UTE) sequence on a 7.0T preclinical spectrometer.

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