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Abstract #4914

Localized spectroscopy of hyperpolarized xenon-129 dissolved in the human head with a dedicated receiver array

Madhwesha Rao1, Neil Stewart1, Graham Norquay1, Fraser Robb1,2, and Jim Wild1

1University Of Sheffield, Sheffield, United Kingdom, 2GE Healthcare Inc, Aurora, OH, United States

This study investigates the spectral signal of hyperpolarized 129Xe dissolved in the human head in vivo using a dedicated radiofrequency receiver coil array. With a 2.5-fold higher signal to noise ratio of the array compared to a conventional transmit-receive radiofrequency coil, we detected 8 spectral peaks compared to 5 peaks reported in an earlier study. From this, we postulate an individual assignment of spectral peaks for hyperpolarized 129Xe dissolved in white matter and soft cartilaginous tissue, which were previously undistinguishable.

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