Abstract #4916

A Pipeline for Quantifying 129Xe Gas Exchange MRI across Pulmonary Disorders

Ziyi Wang¹, Scott Haile Robertson², Jennifer Min Wang³, Mu He⁴, and Bastiaan Driehuys^1,2,5

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³School of Medicine, Duke University, Durham, NC, United States, ⁴Electrical and Computer Engineering, Duke University, Durham, NC, United States, ⁵Radiology, Duke University Medical Center, Durham, NC, United States

With its solubility and abundant chemical shift in different tissues, hyperpolarized ¹²⁹Xe is uniquely suited to imaging pulmonary function. Previous efforts have demonstrated the ability to map gas transfer to interstitial barrier tissues and red blood cells (RBCs) using the gas-phase signal as a reference. Here, we extend this analysis by using a healthy reference cohort to establish relevant thresholds for quantitative display. With this methodology we now produce maps of ventilation, barrier uptake, and RBC transfer that demonstrate readily distinguishable patterns in a variety of obstructive, restrictive and vascular disorders.

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