Abstract #4917

Regional analysis of gas-uptake parameters in the lung using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase imaging: a reproducibility study

Agilo Luitger Kern^1,2, Marcel Gutberlet^1,2, Kun Qing³, Andreas Voskrebenzev^1,2, Filip Klimeš^1,2, Till Kaireit^1,2, Christoph Czerner^1,2, Heike Biller^2,4, Frank Wacker^1,2, Kai Ruppert⁵, Jens Hohlfeld^2,4, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, ⁴Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, ⁵Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

We performed a regional analysis of hyperpolarized ¹²⁹Xe gas-uptake parameters in the lung using localized chemical shift saturation recovery spectroscopy and dissolved-phase imaging with a three-point Dixon method for comparison. Localization of spectroscopic data acquired without spatial encoding was achieved using a 16-channel receive coil and Spectral Localization Achieved by Sensitivity Heterogeneity (SPLASH). The reproducibility of all parameters was studied and coefficients of variation are reported. Localized CSSR data exhibit evidence of gravitational effects in consistency with dissolved-phase imaging. The septal wall thickness derived from evaluation of CSSR data using the Patz model can be determined regionally with high reproducibility.

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