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Abstract #4917

Regional analysis of gas-uptake parameters in the lung using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase imaging: a reproducibility study

Agilo Luitger Kern1,2, Marcel Gutberlet1,2, Kun Qing3, Andreas Voskrebenzev1,2, Filip KlimeŇ°1,2, Till Kaireit1,2, Christoph Czerner1,2, Heike Biller2,4, Frank Wacker1,2, Kai Ruppert5, Jens Hohlfeld2,4, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 4Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, 5Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

We performed a regional analysis of hyperpolarized 129Xe gas-uptake parameters in the lung using localized chemical shift saturation recovery spectroscopy and dissolved-phase imaging with a three-point Dixon method for comparison. Localization of spectroscopic data acquired without spatial encoding was achieved using a 16-channel receive coil and Spectral Localization Achieved by Sensitivity Heterogeneity (SPLASH). The reproducibility of all parameters was studied and coefficients of variation are reported. Localized CSSR data exhibit evidence of gravitational effects in consistency with dissolved-phase imaging. The septal wall thickness derived from evaluation of CSSR data using the Patz model can be determined regionally with high reproducibility.

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