Abstract #4932

Restriction Spectrum Imaging in Breast Cancer: Improved Evaluation of Response to Neoadjuvant Chemotherapy

Rebecca Rakow-Penner¹, Nicholas Albino-Kroesing², Boya Abudu², Nathan White¹, David Karow¹, Hauke Bartsch¹, Joshua Kuperman¹, Dennis Adams³, Natalie Schenker-Ahmed¹, Anne Wallace⁴, Sarah Blair⁴, Haydee Ojeda-Fournier¹, and Anders Dale¹

¹Radiology, University of California San Diego, La Jolla, CA, United States, ²University of California San Diego, La Jolla, CA, United States, ³Pathology, University of California San Diego, La Jolla, CA, United States, ⁴Surgery, University of California San Diego, La Jolla, CA, United States

Restriction spectrum imaging (RSI) is an advanced diffusion imaging technique based on a model with increased sensitivity to cancer cells with high nuclear to cytoplasm ratio. This abstract is the initial evaluation comparing RSI to standard diffusion imaging in breast cancer in assessing response to chemotherapy. RSI Z-scores, in comparison to the ADC, demonstrated increased conspicuity and significance in evaluating response to chemotherapy. RSI may be a more reliable diffusion imaging technique in evaluating response to treatment.

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