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Abstract #4932

Restriction Spectrum Imaging in Breast Cancer: Improved Evaluation of Response to Neoadjuvant Chemotherapy

Rebecca Rakow-Penner1, Nicholas Albino-Kroesing2, Boya Abudu2, Nathan White1, David Karow1, Hauke Bartsch1, Joshua Kuperman1, Dennis Adams3, Natalie Schenker-Ahmed1, Anne Wallace4, Sarah Blair4, Haydee Ojeda-Fournier1, and Anders Dale1

1Radiology, University of California San Diego, La Jolla, CA, United States, 2University of California San Diego, La Jolla, CA, United States, 3Pathology, University of California San Diego, La Jolla, CA, United States, 4Surgery, University of California San Diego, La Jolla, CA, United States

Restriction spectrum imaging (RSI) is an advanced diffusion imaging technique based on a model with increased sensitivity to cancer cells with high nuclear to cytoplasm ratio. This abstract is the initial evaluation comparing RSI to standard diffusion imaging in breast cancer in assessing response to chemotherapy. RSI Z-scores, in comparison to the ADC, demonstrated increased conspicuity and significance in evaluating response to chemotherapy. RSI may be a more reliable diffusion imaging technique in evaluating response to treatment.

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