Pharmacokinetic parameters such as Ktrans, kep and ve can be estimated from contrast enhanced breast MRI using Tofts model. Previous simulation has shown that Ktrans has a maximum bias of 82% at 5s temporal resolutions in the presence of fat. In this work, we have compared the PK parameters estimated from in-phase fat-water, and water-only images in 7 malignant and 4 benign lesions. The presence of fat introduced biases in Ktrans and kep respectively of –0.02 min-1 and 0.01 min-1 in malignant lesions and –0.001 min-1 and –0.003 min-1 in benign lesions, but did not affect the classification of lesions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords