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Abstract #4937

Locally altered lipid profiles: a hallmark of breast cancer metabolism?

Ileana Hancu1, Christopher Sevinsky1, Beatrice Andre2, Fiona Ginty1, Elizabeth Morris2, and Sunitha Thakur2

1GE Global Research Center, Niskayuna, NY, United States, 2Memorial Sloan Kettering Cancer Center, New York City, NY, United States

Cancer cells are known to produce their own fatty acids (FA’s) and co-opt local fat reserves for energy/cell division needs. In this study, single-voxel MRS data were used to assess the spatial/spectral lipid profiles of normal volunteers and subjects with suspicious lesions. Statistically different lipid profiles were found in tumors than in the contralateral breast of cancer patients; the latter were similar to lipid profiles of normal volunteers. Fibrocystic epithelial/breast cancer cell NMR experiments confirmed differential FA composition/uptake for the two cell types. MRI/MRS-based profiling of lipid metabolism may provide a unique tool for better breast cancer tumor detection/characterization.

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