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Abstract #4944

Low-To-High b-Value DWI Ratio Image in Multiparametric MRI of the Prostate: Feasibility, Optimal Combination of b-Values, and Comparison with ADC Maps for the Detection of Prostate Cancer

Franklin Olumba1, Parker Lawson1, Alexander Liu1, Robert E. Lenkinski1, Qing Yuan1, Ivan Pedrosa1, Gaurav Khatri1, Takeshi Yokoo1, Daniel Costa1, and Yin Xi1

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States

This study demonstrated the feasibility of generating a DWI-based image that compares the signal intensity on low versus high b-values (DWIratio image) and compared this model-independent approach to the conventional ADC map in terms of quantitative relative contrast (RC) in signal intensity between lesion and normal tissues and subjective assessment of artifacts, lesion conspicuity, and overall image quality by blinded radiologists. The DWIratio images showed significantly higher RD and lower artifacts and non-inferiority in lesion conspicuity and overall image quality. The model-independent nature of this approach has the potential to improve inter-subject and inter-vendor reproducibility of DWI data for the detection of prostate cancer when compared to ADC maps.

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