This study demonstrated the feasibility of generating a DWI-based image that compares the signal intensity on low versus high b-values (DWIratio image) and compared this model-independent approach to the conventional ADC map in terms of quantitative relative contrast (RC) in signal intensity between lesion and normal tissues and subjective assessment of artifacts, lesion conspicuity, and overall image quality by blinded radiologists. The DWIratio images showed significantly higher RD and lower artifacts and non-inferiority in lesion conspicuity and overall image quality. The model-independent nature of this approach has the potential to improve inter-subject and inter-vendor reproducibility of DWI data for the detection of prostate cancer when compared to ADC maps.
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