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Abstract #4945

Mapping prostatic microscopic anisotropy using linear and spherical b-tensor encoding: A preliminary study

Markus Nilsson1, Filip Szczepankiewicz2, Mikael Skorpil3,4, Carl-Fredrik Westin5, Lennart Blomqvist3,4,6,7, and Fredrik Jäderling6,7

1Clinical Science, Radiology, Lund University, Lund, Sweden, 2Clinical Sciences Lund, Medical Radiation Physics, Lund University, Lund, Sweden, 3Department of Radiology, Uppsala University, Uppsala, Sweden, 4Department of Radiation Sciences, Umeå University, Umeå, Sweden, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 6Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden, 7Department of Diagnostic Radiology, Karolinska University Hospital, Solna, Sweden

Diffusion tensor imaging (DTI) has the potential to improve prostate cancer detection, since anisotropy is expected to correlate with tumor aggressiveness and differentiation. Differences in fractional anisotropy between cancer and normal tissue have been observed, although data is somewhat contradictory. A problem with DTI is its inability to distinguish low anisotropy from high orientation dispersion. In this study, we map the anisotropy independent of orientation in the prostate, by the use of a novel diffusion-encoding technique that permits encodings with variable b-tensor shapes. The microscopic anisotropy was found to be generally higher in cancer than in normal prostatic tissue.

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