Abstract #4969

Magnetization transfer MRI for evaluating bowel fibrosis and inflammation in patients with stricturing Crohn’s disease

Xuehua Li¹, Zhuangnian Fang¹, Siyun Huang¹, Li Huang¹, Zhongwei Zhang², Xu Yan³, Xiaolei Zhu⁴, Jinjiang Lin¹, Mengchen Zhang¹, Mengjie Jiang¹, Shiting Feng¹, Canhui Sun¹, and Ziping Li¹

¹Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China, ²Department of Biomedical Engineering, Cancer Biology and Radiology, Wake Forest School of Medicine, NC, United States, ³MR Collaboration NE Asia, Siemens Healthcare, Shanghai, People's Republic of China, ⁴MR Scientific Marketing NE Asia, Siemens Healthcare, Guangzhou, People's Republic of China

This study aimed to assess the efficacy of Magnetization Transfer MRI (MTI) for evaluating bowel fibrosis and inflammation in patients with stricturing Crohn’s Disease (CD). Bowel wall MTR with normalization to skeletal muscle was calculated and correlated to histologic fibrosis and inflammation as well as amount of type I collagen and vessel density. The results showed that normalized MTRs correlated with histologic fibrosis and type I collagen scores, but did not correlate with inflammation scores or vessel densities. Thus, MTI can accurately detect and distinguish varying degrees of bowel fibrosis with or without coexisting inflammation in human CD.

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