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Abstract #4985

Diffusion kurtosis imaging for differentiating tumor KRAS mutation status in rectal cancer

Yanyan Xu1, Hongliang Sun1, Kaining Shi2, and Wu Wang1

1Radiology, China-Japan Friendship Hospital, Beijing, People's Republic of China, 2Philips Healthcare, China, Beijing, People's Republic of China

Diffusion kurtosis imaging (DKI), which is a non-Gaussian diffusion-weighted model proposed by Jensen et al 1, has the potential to characterize both normal and pathologic tissue 1-3, meanwhile, providing a new option for tumor garde 4 and assessment of treatment response 5-7. Previous studies 1-3, 8 found that DKI could better account for restricted water diffusion within the complex microstructure of most tissues. To our knowledge, however, no study has included evaluation of DKI characteristic in rectal cancer, especially in the aspect of KRAS mutant, which associated with clinical treatment and prognosis of colorectal cancers 9.

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